The refresh is supported by a £500,000 ad push starring characters from the Striker comic strip, which will be rolled out across 49 football grounds around the UK, including Tottenham, Chelsea, Everton and West Ham.
Throughout February, Nuts' branding will appear on ad formats in football grounds including six sheets, in-washroom and concourse screen advertising.
The marketing campaign will also run across other IPC brands including NME, Loaded, Mousebreaker.com and Superbike, as well as on TV and online on Comedy Central and Mtv.co.uk.
New editorial features include 'Nuts about Sport', a humorous take on the week's sporting highlights, a revamped news section, a new fashion feature called 'Nuts 10 Must Haves of the Week', bolder visuals throughout the title and more content on the title's website Nuts.co.uk.
Dominic Smith, Nuts editor, said: "All our development focused on what the readers said they wanted more of from Nuts. They told us they love our classic mix of girls, sport, news, humour, gadgets and gear.
"The new look delivers a fresher, more modern feel to reinforce that mix, while introducing a new range of must-read editorial franchises every week, including an all-new Striker."
Striker, the cult comic strip, was dropped from The Sun in September and will now appear on a weekly basis in Nuts from today.
Nuts was down 24.6% down year on year to 188,532 for the half-year to June 2009, according to the latest ABC figures.