Management is currently holding a series of briefings with MEN's approximately 720 staff to inform them about the cuts.
The structure of MEN Media's local TV channel Channel M, which employs an additional 80 people, is still under a separate review and an announcement will be made in the near future.
None of the newspapers published by MEN, which include the Rochdale Observer and the Stockport Express, will be closed.
However, production of all weeklies will be moved to MEN's Scott Place offices in Manchester and offices closed in Accrington, Ashton, Macclesfield, Oldham, Rochdale, Rossendale, Salford and Wilmslow.
The Stockport office will be kept open but no editorial staff will be based there.
There will also be an announcement tomorrow regarding Guardian Media Group's other regional newspapers business, Surrey and Berkshire Media.
This group includes titles such as the Surrey Advertiser and the Reading Post.
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