Before her tenure at NatMags Frost spent six years at Emap in a number of senior positions, including ad manager for Elle, Red, New Woman and Top Sante.
Frost replaces Claire Portis, who left her role as ad director for IPC's women's general interest magazines in January. She will report to Alex Russell, IPC Southbank's group advertising director.
According to the latest Audit Bureau of Circulations figures, Woman & Home, which is priced at £3.40, registered a circulation of 353,160 between July and December 2008, a lift of 5.1% year on year.
Woman & Home competes against a range of titles including Good Housekeeping.