The platform, launched in September 2007, provides exclusive, on-demand content via the Telegraph's website www.telegraph.co.uk.
Under the terms of the cross-platform deal, Nissan's X-Trail SUV brand will run specially developed pre and post-roll ads around Telegraph TV's weekly Holy Cows news strand.
Alison Reay, digital media director of TMG, said the Nissan tie up was the biggest commercial deal the company had done for Telegraph TV.
The ads, jointly developed by TMG's in-house audiovisual team and creative digital agency Duke, carry on the X-Trail TV ad themes of rock, snow, sand and water.
The deal also includes co-branded ads in the Daily and Sunday Telegraph, traffic drivers on Telegraph.co.uk, and four features in the Sunday Telegraph supplement, Seven.