New Nintendo DS game Animal Crossing Wild World will be advertised on a home page and game page "re-skin" on the popular online gaming site, which will see the brand take over the entire site.
The campaign will be live on the site from today (Tuesday) to 14 April. According to eType, miniclip.com has more than three million unique users in the UK and a total of 27 million worldwide.
Free online game site Miniclip.com has 90 million monthly page impressions worldwide.
The network recently agreed a deal with Warner Bros' new film V for Vendetta, which launched on 17 March. To promote the film, a trailer appears as each game is loading.
EType also represents brands including Friends Reunited, Visit London, The Independent, Bebo, Extreme Sports and National Rail Enquiries. It recently launched New York-based eType USA.