Website for women iVillage and online weight loss company EDiets will provide content, and Conde Nast will provide material from titles GQ, Glamour, and Easy Living. Video will also feature on the site.
The channel will site alongside existing channels like MSN Cars and MSN Money, and follows the recent launch of MSN Video and the re-design of the Entertainment channel.
MSN has also agreed an exclusive content deal with luxury car brand Lexus. The Lexus microsite will contain content based on travel, music, wine, golf and gadgets.
Matthew Whittingham, head of information services at MSN UK, said: "The deals we have secured with top health and lifestyle content providers will provide a compelling contextual environment for advertisers to connect their brands with style conscious consumers."