Formerly known as the Liverpool Daily Post, the Liverpool Post was relaunched in January 2012 as a 100-page weekly with a cover price of £1.
A statement from Trinity Mirror said the decision to close the newspaper, including its website and Liverpool Business Daily E-Edition, followed "an extensive review of its portfolio in the North West".
From daily circulation highs of 20,000 in its heyday, circulation for the weekly newspaper had fallen below 4,000 in recent months.
The company added that there are no planned journalist redundancies as a consequence of this decision and the Post will continue its coverage of Merseyside’s business community in a Post-branded section of the Liverpool Echo.
Trinity Mirror also announced ambitious plans around weekend publishing. The company is to ramp up its publishing operation across the weekend with further investment in the Echo – awarded the UK’s Regional Newspaper of the Year.
Steve Anderson Dixon, Trinity Mirror North West managing director, said: "This is a decision we take with the heaviest of hearts. Sadly, the Liverpool city region no longer generates the demand in terms of advertising or circulation, to sustain both the Post and the Liverpool Echo.
"We are committed to retaining the best of the Post in the Echo. We are also committed to the continued expansion of the Liverpool Echo and have exciting plans on the table for weekend publishing. The Echo is an extraordinary brand and we are thrilled to be expanding its reach and creating jobs as we do so."
Mark Thomas, Liverpool Post editor, added: "That the Post has lasted as long is testimony to generations of brilliant and committed journalists who have worked on it.
"We have a history of brave and independent journalism and excellent coverage of business, arts, and sport. We will ensure we keep those traditions alive within the Liverpool Echo.’"