The car brand will use the new ad product, announced at Channel 4's Upfronts last year, to tailor its interactive elements based on whether the viewer has registered as a man or a woman.
Female registered users will be served with a personality quiz and a link to a competition, while the male registered users will be able to see the car in different shades using an interactive colour palette and watch videos.
Microsoft, O2, Unilever, Nokia and McDonald's are some of the brands to have already signed up to target by audience demographics, location and behavioural patterns on 4oD.
Andy Freeman, the head of digital and relationship marketing, Vauxhall said: "Our approach at Vauxhall is to embrace fresh thinking in all that we do, and to be a leader in the digital space in particular.
"This campaign underlines that approach and Channel 4's Adapt offering was the ideal solution to help us achieve this. For the launch of Adam (our new city car), we know that VoD is a very important channel to reach our target consumer, but we want to ensure that the content we serve to audiences is as relevant as it can be."
Channel 4 now offers eight digital ad products on its video-on-demand service, 4oD, including Ad Pause, Ad Extend, Ad Link, Ad Mix and Ad Bloom.
Vauxhall ads target women (top) and men (bottom)