The show, called 'The Warm Up with Johnny Vaughan' and aired between 11am and 1pm, promises to be a light-hearted look at the weekend’s games, speaking to football fans ahead of kick-offs.
TalkSport and sports television presenter Max Rushden will host 'The Warm-up with Max Rushden' during the same time slot on Sundays.
The new shows follow TalkSport extending its audio rights to broadcast 64 live Barclays Premier League for another three years, to the end of the 2015-16 season.
Vaughan said: "If there is one thing I enjoy more than a Saturday afternoon at the football, it’s a Saturday morning looking forward to an afternoon at the football. 'The Warm Up with Johnny Vaughan' will bring the buzz, the banter and the big dreams of a match-day morning to a radio near you."
Elsewhere, TalkSport presenter Georgie Bingham joins former Newcastle, Portsmouth and Coventry footballer Micky Quinn as the new host of 'Weekend Sports Breakfast' every Saturday and Sunday at the earlier start time of 7am, running until 11am.
Mark Saggers will present 'Sunday Exclusive' and 'Kick Off' on Monday to Thursday nights. TalkSport’s 'Match Day Live' show returns from 1pm, bringing listeners all the goals from around the grounds, plus live and exclusive Barclays Premier League commentary at 5.30pm on a Saturday and 1.30pm on a Sunday.
After the live action, starting with Swansea v Manchester United this Saturday, 'Call Collymore' is back at 7.30pm on Saturday and 4pm on Sunday, giving fans the chance to air their views on all of the weekends games on the fastest post-match phone-in, hosted by Stan Collymore.
On weekdays, Colin Murray's new show between 10am-1pm will feature him accompanied by guests on each day to discuss the days sporting issues.
Former England and Lions hooker Brian Moore and Perry Groves join him every Monday, Micky Gray and Des Kelly on Tuesdays, former German international Didi Hamann and pundit Steve Bunce on Wednesdays, former Liverpool and Spurs midfielder Danny Murphy and Olympic medallist Kelly Sotherton each Thursday, and Perry Groves and Bob Mills rounding off the week each Friday.
The 'Alan Brazil Sports Breakfast' (weekdays 6-10am) will also have new guests alongside Brazil. Neil Warnock will be in the co-host seat on Mondays and Fridays, ex-England cricketer Dominic Cork on Tuesdays, Tottenham, and France football legend David Ginola each Wednesday and Brian Moore on Thursdays.
From this Friday 16 August, Richard Keys and Andy Gray present their new weekly Friday evening show from 7pm to 10pm, providing an in-depth preview of the weekend's games and speaking to some of the biggest names in sport.
Liam Fisher, TalkSport programme director, said: "Undoubtedly, the upcoming Premier League season promises to be one of the most exciting ever and our football rights, allied with the best line-up the station has ever had, means we are the number-one destination for sports fans.
"The new additions to the TalkSport squad give listeners superb insight, analysis and entertainment to help build on the station's highest-ever listening figures.
TalkSport is the official broadcaster of the Barclays Premier League, the FA Cup, England football internationals, the Capital One Cup and Aviva Premiership Rugby, and claims to be the world’s biggest sports radio station with 3.2 million listeners a week in the UK.
The broadcaster is also the global audio partner of the Premier League, having won the right to extend its live commentary of the Barclays Premier League matches to Europe earlier this month.