The print publication will close from the July issue and will continue as online only. The magazine's iPad and iPhone apps will also cease to exist following poor take-up of around 834 downloads a month.
Around 30 staff working on the print edition will now enter a period of statutory consultation, while three staff members working solely on the magazine's digital products will be unaffected.
Easy Living increased its print circulation by 7.1% year on year to 150,020 in the second half of 2012, according to the Audit Bureau of Circulations (ABC), beating titles such as Look and Good Housekeeping, which reported declines.
It is understood Condé Nast felt the longer-term future of the print magazine was unsupportable in the challenging print market, with the rise in circulation primarily supported by multi-bagged sales deals.
It will now concentrate on digital products such as its website, which saw a 466% rise in unique users in the first quarter of 2013. The site attracts around 330,000 unique users a month.
Nicholas Coleridge, managing director of Condé Nast Britain, said: "It is a sad decision to have to take, but we see few encouraging signs in this part of the market, with challenges at the newsstand and an increasing reliance in the sector on multi-bagged offerings.
"Easy Living's print edition has a significant loyal fan base and subscriber base whom we will be reluctant to disappoint, and a particularly talented editorial and publishing staff. However, our digital reach far outweighs that of print, and Easy Living is thriving online."