The deal, brokered through William Hill's retained media agency the7stars, will include live, delayed and highlights coverage with pre and end-break bumpers. The sponsorship also extends to ESPN's preview and review shows around the matches.
The betting company will also sponsor the broadcaster’s forthcoming mobile app for football news and information site, ESPNsoccernet.
William Hill will be integrated into the app with a "bet now" button enabling users to place bets on football action as it happens.
As part of the multi-platform deal, William Hill will also run display banners and rich-media ads online with ESPNsoccernet.
Alan Fagan, director advertising sales at ESPN Europe, Middle East and Africa (EMEA), said: "Our multi-platform coverage of Europe’s top football leagues is a popular part of the ESPN offering to fans and brands alike.
"Our agreement with William Hill, one of the UK's leading brands, reflects how we can deliver value to top-flight advertisers, connecting them with loyal and passionate UK football fans across multiple screens."
Kristof Fahy, chief marketing officer at William Hill, said: "ESPN is one of the leading names in sports media and we're really looking forward to working with them. This multi-platform deal will enable us to promote our brand and services to millions of sports fans across the UK."
In January this year William Hill appointed Beattie McGuinness Bungay to handle its advertising account and briefed the agency to showcase a series of innovations planned for the coming year.
In 2010 the bookmaker introduced a campaign that used the strapline "I will," featuring football fans making promises to themselves.
Follow Mark Banham on Twitter @Banham72