Cosmopolitan, published by Hearst Magazines International, currently boasts 61 international editions, having most recently launched in Mongolia in December 2010.
Cosmo Middle East will launch a March edition on newsstands next month, published under contract through consumer and business magazine publisher ITP.
Hearst already publishes two other titles in the region – the high-end glossies Harper’s Bazaar and Esquire.
A spokesman for Hearst said: "The magazine's engaging, upbeat and informative tone will resonate with the young women of the region."
Cosmopolitan Middle East will be published in English, with an initial print run of 15,000 copies.
The edition will be circulated across the GCC (Cooperation Council for the Arab States of the Gulf) and Lebanon, and will be available at all major retail outlets.
Walid Akawi, chief executive of ITP, said: "The Middle East has one of the youngest populations in the world, so introducing a local edition of the world's best-selling magazine for young women seems an obvious decision."
Like its western counterparts, Cosmopolitan’s Middle Eastern edition will focus on fashion and beauty, relationships, women's health, and entertainment.
The magazine, which was founded in 1886, is published in 32 languages and is distributed in more than 100 countries.
Louise Court, editor of Cosmopolitan in the UK, said: "Cosmopolitan is the world's leading young women's consumer magazine. We already publish in a number of Muslim countries such as Indonesia and Turkey. The backbone of Cosmo is about being the best you can in all areas of your life.
"Models are different across the brands so you edit the magazine to be relevant to your readership. The brand values of each edition are the same but we are totally sensitive to the market."
In the UK, Cosmopolitan is expanding its brand onto eBooks, following the recent launch of Cosmopolitan on the Zinio platform.
Earlier this month, it was revealed that Hearst Corporation is in exclusive talks with Lagardère, the French owner of Hachette Filipacchi, over the sale of Lagardère's international magazines