ITV has agreed a deal with Peel Media that will move the channel's production base from Manchester to Salford Quays in 2012.
'Coronation Street' is expected to have its own production and studio centre built in the area, on a 7.7-acre site at Trafford Wharf.
The programme's production site will house a new external film set, two sound-stage buildings, specialist production facilities and offices, dressing rooms, and cast and staff meeting spaces.
The rest of ITV’s production will be housed within the MediaCityUK’s Orange Building, across several floors.
Adam Crozier, chief executive of ITV, said: "It’s terrific news for ITV and all of our people based in Manchester that we have agreed this deal with Peel Media Ltd. This continues our long and successful relationship with the region, which has played such a key part in ITV’s heritage as a programme maker.
"Coronation Street is an incredible brand and, as we celebrate its 50th anniversary, it's fantastic news that we are able to invest in the construction of a modern production centre to ensure that the nation’s best loved soap remains at the top of its game for another half a century."
ITV Studios is the region's biggest producer of original content and makes more than 700 hours of programming each year.
The move will go some way to redressing the London bias inherent within the UK's media powerbase. The BBC has already confirmed that around 2,000 staff will move into MediaCityUK in 2011 from five departments, including Radio Five Live, Children’s and Sport.