Among the brands working in association with Vogue for the event are fashion and beauty retailers ASOS, Net-a-Porter, Matches, Browns, Astley Clarke, My-Wardrobe and Space NK.
The retailers will provide online shoppers with exclusive fashion and beauty offers, bespoke video content and competitions from 5pm to midnight.
A percentage of all sales made on the night will go to Kids Company, which provides practical, emotional and educational support to vulnerable inner city children.
The site will be updated every five minutes throughout the evening by the Vogue.com team, who will be blogging advice about the offers available.
The event is a brand spin-off from Vogue's Fashion's Night Out, a global initiative launched in 2009 by Anna Wintour, the former US Vogue editor.
Sixteen countries took part in the event including the UK, the US, Germany, India, Turkey, Japan, Russia, Taiwan, Italy, Portugal, Greece, Australia, China, Korea, Spain and France.
Stores in the participating countries opened their doors until late evening, providing consumers with exclusive offers, events, promotions and catwalk shows.
This year's Fashion's Night Out was held in September and attracted style celebrities, including Claudia Schiffer, Giorgio Armani and Stella McCartney, to the London event.
Profits from T-shirts and tote bags sold by Vogue for the event went to Kids Company, run by philanthropist Camila Batmanghelidjh.
Dolly Jones, editor of Vogue.com, said: "We're delighted to be in a position at Vogue.com to undertake this enterprise and to bring the world of fashion into the hands of dedicated shoppers for this unique and exciting occasion. It's a first for the online community and we're incredibly proud to be its host."
In the lead-up to the night, shoppers can plan their online shopping itinerary by logging on to the microsite www.vogue.co.uk/fashions-night-in, which will list all of the activity planned for the evening.